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Fig. 1. Schematic representation of the primary structures of Pds5A and Pds5B from human and Xenopus. The yellow bars indicate the `core' region conserved between Pds5A and Pds5B, which contains multiple HEAT repeats (shown in magenta). The C-termini of Pds5A (blue line) and Pds5B (red line) display little similarity. Consensus sites for Cdk phosphorylation are clustered in the C-terminal domain of Pds5B (indicated by thin, vertical red lines) but not of Pds5A. The shadowed N-terminal region of Xenopus Pds5B has not yet been cloned.





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