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Fig. 9. Schematic diagram illustrating the ability of multiple serine proteases to activate MMP-1 and MMP-10 zymogens to control capillary tube regression in 3D collagen matrices. MMP-1 is activated directly by either serine proteases or activated MMP-10 (bold arrow). MMP-10 and serine proteases act synergistically to super-activate MMP-1, leading to type I collagen degradation, capillary tube regression and EC apoptosis. MMP-10 contributes to capillary tube regression by activating MMP-1 zymogen (bold arrows) and may contribute to degradation of basement membrane matrix leading also to tube regression and apoptosis (dashed arrow).





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