spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

First published online May 28, 2005

Journal of Cell Science 118, 1103e (2005)
© The Company of Biologists Limited
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in JCS
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Search for Related Content

In this issue

Co-Arperative mRNA transport


The seven-subunit, Arp2/3 complex localizes to the leading protrusions of migrating cells, where it nucleates actin assembly. On p. 2425, Gang Liu and colleagues hypothesize that an efficient way to target such a large, stable complex to a specific region of the cell might be to localize the mRNAs for its component subunits to the same region. By using sensitive FISH techniques, the authors show that, as predicted, all the mRNAs for the Arp2/3 complex are targeted to the leading protrusions of chick embryo and human foreskin fibroblasts. This localization depends on serum factors, which suggests that it represents a cellular response to extracellular stimuli, and on actin filaments, microtubules and the presence of myosin motors. How the Arp2/3-complex mRNAs are localized to the leading protrusions of fibroblasts and then anchored is not yet known, but these results provide the first evidence for localization of all the mRNAs of a multisubunit protein complex to its site of assembly and function.


Related articles in JCS:

Localization of all seven messenger RNAs for the actin-polymerization nucleator Arp2/3 complex in the protrusions of fibroblasts
Lisa A. Mingle, Nataly N. Okuhama, Jian Shi, Robert H. Singer, John Condeelis, and Gang Liu
JCS 2005 118: 2425-2433. [Abstract] [Full Text]  




This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in JCS
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Search for Related Content