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Fig. 1. Schematic representation of the cadherin superfamily. Fat cadherin is the largest cadherin, with 34 cadherin repeats. Blue ovals and green circles indicate cadherin repeats and laminin A-G motifs, respectively. Yellow boxes indicate EGF motifs. The red box in Flamingo indicates the flamingo box. Classical cadherin is believed to associate with the actin cytoskeleton through the ß-catenin and {alpha}-catenin complex (pink oval). Desmosomal cadherins associate with intermediate filaments through plakoglobin/desmoplakin (light blue oval). The variously colored rectangles indicate the intracellular domains of the cadherins.





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