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Fig. 2. Members of the Fat and Dachsous cadherin subfamilies. Drosophila has two Fat cadherins (Fat and Fat-like) and one Dachsous cadherin. In vertebrates, four Fat cadherins (Fat-J, Fat1, Fat2 and Fat3) and two Dachsous cadherins (Dachsous 1 and Dachsous 2) have been reported. Fat-J is probably the counterpart of Drosophila Fat. Fat1 and Fat3 resemble each other in their overall sequences, and they show weak similarity to Drosophila Fat-like. The precise length of Dachsous 2 has not been determined. The rectangular boxes depict the intracellular domains of the various Fats. The regions between the last cadherin repeat and the first EGF motif or the laminin A-G motif (for Fat2) of Fat cadherins show weak similarities to the Flamingo box, which is conserved in Flamingo cadherins (Usui et al., 1999).





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