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Fig. 5. Fat1 appears to be involved in cell-cell contacts and lamellipodial dynamics at the leading edge. Fat1 localizes to early cell-cell contact sites, lamellipodial edges and the basolateral portion of polarized epithelia (red). Fat1 regulates actin dynamics by binding to Ena/VASP proteins at these sites. Whether Fat1 cadherins undergo homophilic interactions remains unknown.





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