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Fig. 5. Impaired keratinocyte migration in HB–/– mice. (A) Serial sections were prepared, and the epidermis was stained with anti-keratin antibody. Computer-assisted morphometric analysis was performed and the ratio of the leading edge to initial wound length was calculated. (B) Immunohistochemical staining of wound healing assay at day 7. Scale bar: 500 µm. (C) Measurements of leading edge ratio in HBlox/lox and HB–/– mice. The leading edge ratio was significantly decreased in HB–/– mice (n=9) at day 7. *P<0.01.





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