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Fig. 8. Freeze-fracture examination of the distribution of intra-membraneous particles (IMP) on the plasma membrane P-face in K⁺ and K^– IE. (A) Low power micrograph of a K⁺ IE in which the fracture plane passes through the erythrocyte plasma membrane and cytoplasm to the membrane of the parasitophorous vacuole (PV), which contains the parasite. Note that there is an uneven distribution of the intra-membraneous particle (IMP) within the erythrocyte plasma membrane (arrowheads). Bar, 1 µm. (B) Detail of a fracture through a K⁺ IE plasma membrane. Note the concentric ring formed from focal organisation of IMP and a zone free of IMP. IMP form foci at sites underlying knob (arrowheads). Bar, 100 nm. (C) Low power micrograph of a K^– IE in which the fracture plane passes through the erythrocyte plasma membrane and cytoplasm to reveal the parasitophorous vacuole (PV). Bar, 1 µm. (D) Detail of the K^– erythrocyte plasma membrane (boxed area in C) showing the even distribution of IMP in the absence of knob formation. Bar, 100 nm. (E) Detail of the plasma membrane of an uninfected erythrocyte for comparison to D to illustrate the lack of IMP rearrangement in the absence of knobs. Bar, 100 nm.

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