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Fig. 10. Molecular models of mouse LR CRH2. (A) CRH2 residues that become buried in the leptin/CRH2 interface, coloured according to the area that becomes buried (cyan, <25 Å2; blue, 25-50 Å2; green, >50 Å2). (B) CRH2 residues that lead to a drastic increase of leptin binding to CRH2 and LR activation upon mutation.





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