spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

First published online June 8, 2005

Journal of Cell Science 118, 1201e (2005)
© The Company of Biologists Limited
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in JCS
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Search for Related Content

In this issue

Cytoskeletal roles for smart Alix


Alix (apotosis linked gene 2 interacting protein X) has been implicated in the biogenesis of the multivesicular bodies that mediate transport between early endosomes and late endosomes/lysosomes. However, its exact cellular function is unclear. Harald Stenmark and colleagues now propose that Alix helps to connect the cortical actin skeleton to endosomes (see p. 2625-2635). The authors report that downregulation of Alix expression in HeLa cells by RNAi causes early and recycling endosomes to redistribute from a peripheral to a perinuclear location. Surprisingly, this redistribution does not affect transferrin recycling or the degradation of endocytosed epidermal growth factor receptors. Alix depletion does, however, cause an accumulation of unusual actin structures similar to those seen on depletion of HipR, a protein that facilitates the interaction between the cortical actin skeleton and the endocytic machinery. These and other results suggest that Alix also acts at this interface, although what it does there and how it connects with the actin cytoskeleton remain to be determined.


Related articles in JCS:

Alix regulates cortical actin and the spatial distribution of endosomes
Alicia Cabezas, Kristi G. Bache, Andreas Brech, and Harald Stenmark
JCS 2005 118: 2625-2635. [Abstract] [Full Text]  




This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in JCS
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Search for Related Content