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Fig. 5. HOXA3 upregulates MMP-14 and uPAR gene expression in vivo during wound repair. (a) Western blot of HOXA3/myc/His fusion protein in diabetic wound tissue harvested at 4 days after treatment with control or HOXA3 expression plasmids. (b) Analysis of murine MMP-14 expression (relative to 18S RNA expression) in heterozygous (wt), untreated Lepr^db/Lepr^db homozygotes (db) or homozygotes treated with HOXA3 expression plasmids (db +HOXA3). **P<0.05 when compared with expression in untreated homozygotes. Results are the mean±s.d. of two experiments. (c) Quantitative real time PCR analysis of murine uPAR mRNA expression (relative to GUS expression) in Lepr^db/Lepr^db homozygotes treated with control or HOXA3 expression plasmids. **P<0.01 compared with expression in control cells. Results are the mean±s.d. of four experiments. (d) Western blot analysis of uPAR expression in control or HOXA3-treated wounds.

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