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Fig. 4. Cdc42-activated Pak is concentrated at the leading edge. Active Pak is localized at the front of the cell upon wounding. Phospho-Pak (PPak) is specifically detected at the front of cells microinjected with a wild-type pRK5-MYC::Pak1 construct (not shown), in discrete foci that are distinct from thick ruffled areas of the cell. Upon inhibition of Cdc42 by co-injection of pRK5-HA::WASp CRIB (not shown), Pak is no longer activated (expression level of pRK5-MYC::Pak1 wt is comparable to control cells, not shown). Bars, 20 µm.





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