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Fig. 5. Activated RhoB prevents Rab5-dependent endosome fusion. Cells were microinjected with the cDNA for the activated mutant of Rab5 (myc-Rab5Q79L) alone (a) or in combination with myc-RhoBG14V (b,b'). Rab5 was detected with the mouse 4F11 monoclonal antibody and RhoB with the rabbit sc-119 polyclonal antibody. Expression of myc-Rab5Q79L induced the formation of large endosomes that localised to the juxtanuclear area (a). Co-expressed myc-Rab5Q79L and myc-RhoBG14V co-localised in smaller endosomes scattered over the cell (b,b', arrows). Bars: 10 µm.





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