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Figure 6


Fig. 6. uPAR mediates uPA-dependent Tyk2/Stat3 pathway activation in MCs. A. Quiescent MCs were infected with LV-uPARsi and time-dependent downregulation of uPAR expression was monitored by immunoblotting, using clone R3 monoclonal anti-uPAR antibody. MCs infected with LV-uPARsi or mock viruses were treated with 10 nM uPA for the indicated times at day 3 after infection and phosphorylated Tyk2 (B) or Stat3 (C) proteins were visualized in cell lysates by immunoblotting with specific anti-phospho-Tyk2 and anti-(P)-Tyr-Stat3 antibody, respectively. MCs incubated in medium without uPA served as a control. The upper panels is representative of three independent experiments. Quantification (mean ± s.e.m.) of the results by densitometry is shown below. Significance between control unstimulated and stimulated cells was determined by Student's t-test (*P<0.05).





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