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Fig. 1. Schematic drawing of the sucrase-isomaltase alanine scanning-mutants. The primary sequence of the SI polypeptide between amino acids W₁₀₈₈ and S₁₁₀₈ is depicted in single letter code together with the SI cDNA sequence. Q₁₀₉₈ is indicated in bold; this residue is substituted by P in phenotype II of CSID. The Ala triplets (Ala1 to Ala6) are boxed and shown underneath the corresponding mutated SI sequences. The individual Ala mutants are shown underneath the corresponding substituted amino acid residue. Another Ala triplet was constructed to encompass Q₁₀₉₈ and two upstream residues, N₁₀₉₆ and D₁₀₉₇ (denoted Ala3Q). The Ala triple or single mutants in grey boxes are responsible for the phenotype II of CSID.

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