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First published online June 23, 2005

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Peri-implantation at a PINCH

During the development of multicellular organisms, integrins act through integrin-associated molecules to regulate essential aspects of cell-cell and cell-matrix adhesion, cell polarity and cell survival. On p. 2913, Reinhard Fässler and co-authors report that the integrin-associated protein PINCH1 regulates all four of these processes during the peri-implantation stage of mouse development. PINCH1 interacts with integrin cytoplasmic tails at focal adhesions via integrin-linked kinase (ILK). The authors show that, like ß1-integrin- and Ilk-deficient mice, mouse embryos carrying a disrupted PINCH1 gene arrest at the peri-implantation stage. To pinpoint this phenotype, the authors examined embryoid bodies (EBs), an experimental model for this stage of development. Although PINCH1-null EBs show many of the same defects as ß1-integrin- and Ilk-mutant EBs (including abnormal epiblast polarity and detachment of cells from matrix), they also exhibit abnormal cell-cell adhesion and increased endodermal apoptosis. Thus, the authors conclude, PINCH1 acts in both an ILK-dependent and an ILK-independent manner during mouse peri-implantation.

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Related articles in JCS:

PINCH1 regulates cell-matrix and cell-cell adhesions, cell polarity and cell survival during the peri-implantation stage

Shaohua Li, Randi Bordoy, Fabio Stanchi, Markus Moser, Attila Braun, Oliver Kudlacek, Ulla M. Wewer, Peter D. Yurchenco, and Reinhard Fässler
JCS 2005 118: 2913-2921. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?