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Fig. 1. Phylogenetic tree and domain organizations of the 15 START-domain proteins in humans. START domain sequences were aligned by the Eclustalw program (Genetics Computer Group, Madison, WI). The phylogenetic tree was drawn with the drawtree software [J. Felsenstein, 1993, PHYLIP (Phylogeny Inference Package) v.3.5c, Department of Genome Sciences, University of Washington, Seattle, WA]. Abbreviations: Mt, mitochondrial targeting motif; MENTAL, MLN64 N-terminal domain; PH, pleckstrin homology domain; FFAT, two phenylalanines in an acidic tract motif responsible for ER targeting; RHOGAP, Rho-GTPase-activating-protein domain; SAM, sterile alpha motif; THIO, acyl-CoA thioesterase domain.





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