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Fig. 4. Dendrograms showing similarity in localization between (A) the GFP-UCE wild type, GFP-UCE 502 Stop, GFP-UCE Y⁴⁸⁸A/502 Stop and double mutant constructs of the Q⁴⁹²EMNGEPL sequence in the cytoplasmic tail of UCE, and (B) the wild-type and all 11 mutant constructs. The constructs are clustered based on Mahalonobis distance calculated on the SLF20 set of subcellular localization features. The similarity in pattern between any two constructs is inversely proportional to the vertical distance along the path connecting them. For example, wild-type and 502 Stop are the most similar pair of constructs. These dendrograms are available at http://murphylab.web.cmu.edu/services/PSLID/HeLa_UCE/ with a browser interface that allows the underlying images for any branch to be displayed interactively.

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