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Fig. 8. Tf and TfR accumulate in a juxtanuclear cluster of tubulo-vesicular organelles in HeLa cells treated with CI-976. Cells were treated for 10 minutes with DMSO as a solvent control (A,B) or 20 µM CI-976 (C,D). TRITC-Tf (A,C) was then added for 45 minutes at 37°C. Cells were then fixed and stained for immunofluorescence localization of TfR (B,D).





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