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Fig. 6. Interaction of a non-canonical tyrosine-based endocytic motif with µ2-adaptin. (A) Structure of the signal-binding domain of µ2 complexed with a peptide corresponding to P2X4 amino acids 375-384. (B) Electron density (mFo-DFc) map of the P2X4 peptide bound to µ2; {sigma} level is 2.56. (C) Overlay of the P2X4 endocytic motif (YXXGL, green) with that of TGN38 (YXXL, gold), to compare binding of non-canonical and canonical tyrosine-based endocytic motifs. (D) Close-up view of the second hydrophobic pocket of µ2 to compare the entry and co-ordination of the Y+4 and Y+3 leucine residues of YXXGL and YXXL, respectively.





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