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Fig. 2. Distribution of IP3 receptor isoforms in myonuclei. Co-immunofluorescence analysis of IP3 receptor isoforms with LAP 2 (a specific marker for the inner nuclear membrane). (A) Labels for both type-1 IP3R (upper image), and LAP 2 (center image) in the nuclear envelope were superimposed (yellow in bottom panel). (B) The labels for both type-2 IP3R (upper image) and LAP 2 (middle image) in the reticulum and nuclei respectively did not colocalize when images were superimposed (bottom image). (C) Immunolabel for type-3 IP3R (upper image) and LAP2 (middle image) show no colocalization (bottom image). Arrows show invaginations of the nuclear envelope towards the nucleoplasm colocalizing with type-1 IP3R, but not with either type-2 or type-3 IP3R. Bar, 10 µm.





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