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Fig. 3. Transcriptional activity of EGR and NF-{kappa}B complexes for inflammatory gene promoters. Human 293 kidney cells were transfected with reporter constructs containing the human promoters for the genes encoding (A) IL-2,(B) TNF-{alpha} and (C) ICAM-1. The reporter constructs were transfected together with the indicated expression vectors. The transcriptional activity is shown as fold induction of the activity of the reporter construct alone, which was set to 1. Mean values and standard deviations are shown from at least three independent experiments performed on different days and measured in triplicate.





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