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Fig. 6. Inhibitory effect of synthetic peptides. Synthetic peptides representing either the major interaction domain of EGR-4 (peptide 1, amino acids 455-468) or an unspecific scrambled sequence (peptide 2) were used as inhibitors for EGR-4/p65 complex formation. NF-{kappa}B p65 was preincubated with peptide 1 (A) or peptide 2 (B) and bound to an EGR-4 matrix. (C) The specific inhibitory effect of peptide 1 was confirmed by surface plasmon resonance. p65 preincubated with peptide 1 or 2 was applied to the fluid phase and binding to immobilized EGR-4 was analysed. One representative experiment out of five is shown.





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