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Fig. 7. Localization of the p65 interaction domain in the crystal structure of the EGR zinc-finger domain bound to DNA. The structure of the zinc-finger domain of Zif268 was used as a template to localize the p65 interaction domain of EGR-4. (A) Conservation of amino acids in zinc finger III between EGR-1 and EGR-4. Positively charged amino acids involved in interaction are shown in blue. The conserved amino acids that complex the zinc ion and form the zinc-finger structure are highlighted in yellow. (B) Zinc finger I is shown in light gray, zinc finger II in dark gray and zinc finger III in black. The positions of the amino acids of EGR-4 that bind p65 are shown in red.





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