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Fig. 10. Functional role of PKC{alpha}. CHO{alpha}Vß3 cells (left panels) and osteoclast cultures (right panels) were treated with Gö6976 as described in the Materials and Methods and investigated for (A,B) adhesion to LM609, (C,D) migration through LM609, (E) invasion through Matrigel and (F) bone resorption. Results are the mean ± s.e.m. from three independent experiments. *P<0.005. The times of each assay are as follows: (A,B) 30 minutes; (C,E) 4 hours; (D) 12 hours; (F) 48 hours.





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