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Fig. 4. Paracrine and autocrine effects on keratinocyte proliferation in absence of CTSL. (A) Effects of fibroblast conditioned media on proliferation of ctsl+/+ (pale gray columns) and ctsl-/- keratinocytes (dark gray columns). Proliferation was measured by [3H]thymidine incorporation into DNA. *P<0.05 compared with all other groups. (B) Effects of keratinocyte conditioned media on proliferation of ctsl+/+ (pale gray columns) and ctsl-/- keratinocytes (dark gray columns). *P<0.05 compared with ctsl+/+; ***P<0.001 compared with all other groups.





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