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Fig. 1. Various cell lines are differently affected by pre-fibrillar aggregates. Cell viability was checked by the MTT test, after supplementing cell culture media with 2.0 µM HypF-N pre-fibrillar aggregates. Values are relative to control cells treated with the soluble HypF-N (means ±s.d.). The inset shows the percentage of cell death in the most susceptible cell type (Hend) exposed to varying amounts of fibrillar (F) or pre-fibrillar (G) aggregates. Hend cells were pre-treated to enrich the cholesterol content of the plasma membrane before exposure to pre-fibrillar aggregates (G+cholesterol). For technical details see under Materials and Methods. The reported values are representative of six independent experiments, each performed in duplicate. ^*P $≤$ 0.05, significant difference vs cells exposed to the soluble HypF-N. ^**P $≤$ 0.05, significant difference vs not pre-treated cells exposed to the HypF-N pre-fibrillar aggregates.

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