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Fig. 2. (A) ATF3 is upregulated in LKs of in vitro scrape wounds. Monolayer cultures of quiescent HKs were fixed at (a) 0, (b) 3, (c) 6 and (d) 12 hours after scrape wounding. ATF3 protein was undetectable in quiescent unwounded cells at 0 hour. ATF3 protein expression levels are elevated and the protein is localized to the nucleus of LKs within 3 to 6 hours and returned to baseline levels within 12 hours. Following keratinocytes distant from the wound margin did not upregulate ATF3 protein expression. White arrows identify LKs. (B) ATF3 is upregulated in LKs that assemble focal adhesions at the wound edge. After wounding (2 hours), ATF3 was selectively expressed in nuclei (large white arrows) of LKs at the wound margin but not following cells. The LKs expressing ATF3 also assembled focal adhesions detected with anti-paxillin antibody (small white arrows). Bar, 25 µm.





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