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Fig. 5. ROS is induced in other temperature-sensitive initiation mutants and is amplified by additional loci that also respond to DNA damage. (A) Temperature- and time-dependent induction of ROS in cdc6-1, GA1410 orc2-1 and wild-type (W303) cells. (B) ROS induction in wild-type and orc2-1 segregants of a GA1410 orc2-1 x ORC2 mating shifted to 37°C for 6 hours. (C) ROS induction by DNA-damaging agents in parental wild-type (W303) or GA1410 orc2-1 cells. (D) ROS induction by DNA-damaging agents in wild-type (ORC2) segregants of the GA1410 orc2-1 x ORC2 mating that do [ROS (+)] or do not [ROS (–)] harbor the additional determinants of ROS present in GA1410 orc2-1 cells. Cells were exposed for 6 hours at 23°C to the DNA-damaging agent adozelesin (ado) at a final concentration of 4 µM or to 0.1% methylmethane sulfonate (MMS).





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