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Fig. 1. The terminal end bud (TEB). The TEB appears at the onset of puberty, undergoing rapid growth and differentiation. (A) Expression of Sca1 is enriched in TEBs (arrows) and ducts of six-week-old mice. Micrograph showing live imaging of GFP expression in Sca1-GFP knock-in mice (Sca1-GFP mice kindly provided by T. A. Graubert, Washington University; glands prepared and image captured with help from M. T. Lewis, Baylor College of Medicine). (B) Schematic view of the TEB. A cap cell layer surrounds the body cells. The cap cells can take on either a myoepithelial lineage or a luminal epithelial lineage and therefore are thought to be multipotent stem cells. Differentiated myoepithelial and luminal epithelial cells line the neck of the TEB and the subtending duct. (C) Section, stained with hematoxylin and eosin, of a midpregnant mammary gland from C57BL/6 mice indicating the locations of the ductal and alveolar cells. (D) Schematic view of the ductal and alveolar cells during midpregnancy. The ducts are surrounded by a basal layer of overlapping myoepithelial cells, whereas the alveoli cells are surrounded by a basket-like layer of myoepithelial cells.

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