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Fig. 6. (A) Double immunofluorescence micrographs showing the distributions of pTyr-p85 and tyrosinated {alpha}-tubulin in hippocampal pyramidal neurons after 24 hours in culture. Cells were incubated in control medium or in the presence of 10 nM IGF-1 or insulin for 5 minutes. pTyr-p85, indicating activation of PI3K, is present only in the cells stimulated with IGF-1 and is evident especially in the distal axon and growth cone. Bar, 20 µm. (B) Inmunofluorescence micrographs showing the distribution of pTyr-p85 in hippocampal pyramidal neurons after 36 hours in culture and incubated for 5 minutes with 10 nM IGF-1 (top) or in control medium (bottom). Note the intense staining of the distal third and the growth cone of the axon. Bar, 20 µm (left), 5 µm (right).





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