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Fig. 5. Schematic representation of the regulatory light-chain of myosin (RLC) and the RLC-binding sequence of myosin heavy-chain. Sequences of the RLC and myosin heavy-chain were derived from the following crystal structures: NCBI numbers 1QVI and 1WDC (Gourinath et al., 2003; Houdusse et al., 1997). The FHC RLC one-point missense mutations are labeled. The A13T and F18L mutations are in the region of RLC that has not been solved in any of the existing crystal structures. The D166V mutation of RLC, the last identified to date, is incorrectly indicated as D166L in the original paper by Richard et al. (Richard et al., 2003) (revised information of P. Charron).

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