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Fig. 3. The GP-GPo values of Laurdan in astrocyte membranes at 37°C. The GP-GPo (GPo is the GP of control sample without H2O2 treatment) increased with increasing concentration of H2O2 (2 hours treatment) (P<0.05), indicating that the plasma membranes became more gel-like. Pretreating astrocytes with the p38 MAPK inhibitor SB203580 (20 µM, 30 minutes) reduced the change in phase properties resulting from oxidative stress (P<0.05). Values are the mean ± s.d. of three independent experiments.
