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Fig. 5. Homologous pairing and ectopic association of regions flanking the lac operator transgene. (A) Percentage of homologously paired MGL6 loci, homologously paired F18C1 loci and association between both regions in the wild type, hemizygous and homozygous EL702C nuclei without or after Dex treatment. Significant differences *P<0.05 and ***P<0.001 were found compared to levels in the wild type determined using {chi}2 test. (B) Schemes of chromosome 3 (wild type and EL702C) showing the position of BACs MGL6 and F18C1 used for FISH. (C) Homozygous EL702C nuclei showing homologous pairing of MGL6 (top) or ectopic association intrachromosomally or between two homologues (bottom). Bars, 3 µm.





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