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Fig. 1. SNARE function in trafficking and SNARE domain structure. (A) Vesicle trafficking. The stages of vesicle budding and fusion are shown. During SNARE activation, SNAREs become disassembled with the help of NSF, 
-SNAP and ATP. Budding includes uptake of the v-SNARE, Rab proteins and tethers, which assemble before or during tethering into a complete complex. Fusion requires SNARE complex assembly and lipid mixing. (B) Domain structure of selected SNAREs. Lipid anchors on Ykt6 and SNAP-25 are indicated. (C) The HABC N-terminal domain of syntaxin (PDB accession number 1BR0) (Fernandez et al., 1998). (D) The Ykt6 N-terminal longin domain (1H8M) (Tochio et al., 2001).
