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Fig. 8. CamKII-induced meiotic progression is blocked by a spindle checkpoint. (A-C) Both nocodazole and Mad2 could inhibit Sr2+-induced exit from MetII arrest. (A,B) 100 ng/nl nocodazole completely inhibited parthenogenetic activation by Sr2+ medium as judged by Hoechst staining but 10 ng/ml nocodazole had little effect. (C) Over expression of Mad2::YFP similarly blocked cell-cycle progression. (D) A spindle checkpoint induced by either nocodazole (100 ng/ml) or Mad2 blocked CA-CamKII-induced resumption of meiosis. The number of eggs per treatment group is indicated in parenthesis. In B and C the arrow indicates the MetII spindle and the arrowhead, decondensed chromatin in a pronucleus. Scale bar: 20 µm.





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