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Fig. 3. Intrachromosome territory organisation of NANOG and OCT4. (A) Position (mean±s.e.m.) in µm, relative to the inside, edge or outside CTs, for loci including NANOG and OCT4, as well as loci flanking OCT4, in the nuclei of hES cells ( ${square}$ ) and LCLs ( ${blacksquare}$ ) (n=100). Negative values indicate localisation outside the CT. The map of the genomic regions around OCT4 and NANOG (according to NCBI build 35) is shown below. Genes present in the BACs used are highlighted in bold. (B) Histogram of the distribution of FISH signals from a BAC containing OCT4, relative to the edge of the chromosome 6p CT, in nuclei from hES cells (open bars) and LCLs (filled bars). Negative distance indicates localisation outside the visible limits of the CT (n=100).

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