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Fig. 4. Centromere and telomere localisation in hES cells. (A) Localisation of centromeres (CREST, red), and nucleoli (Ki67, green) in single image frames, taken at 0.75 µm intervals, through the z-axis of hES cell nuclei counterstained with DAPI (blue). Note the absence of centromeres from the nuclear periphery. (B) Mean (±s.e.m.) proportion of centromeres per cell that are associated with the nuclear periphery (left), the nucleolus (middle), or neither of these nuclear compartments (right), in H1 ES cells (open bars), LCLs (filled bars) and fibroblasts (hatched bars) (n=20). The mean (±s.e.m.) distribution of (C) centromeres and (D) telomeres through the z-plane from the top (0) to the bottom (1) of nuclei from ES, LCL and fibroblast cells (n=20). Bar, 5 µm.





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