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Fig. 6. Gene profiling by DNA microarray. (A) Loading plot projected on the first two principal components relative to the PCA of data from the three sets of arrays comparing the transcriptome of untreated hMSCs with 6 and 48 hour-treated hMSCs and foetal brain (positive control). (B) Plot of the average fold changes relative to all genes with detectable expression in all three sets of array experiments. The dimmed field comprising the range between -1.5 and 1.5-fold change contains the genes in which expression is not significantly modulated between the samples and the reference (i.e. uninduced hMSCs). (C,D) Intersections between the sets of the 100 genes most significantly modulated by DMSO/BHA treatment at the specified times and the set of genes differentially expressed between untreated hMSCs and foetal brain (positive control, C) or adult liver (negative control, D).





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