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First published online September 9, 2005

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Budding role for PKC

In eukaryotes, protein kinase C (PKC) is implicated in the regulation of many important cellular processes, including proliferation and polarized growth. In budding yeast, a single PKC (Pkc1p) activates the Mpk1p MAP kinase pathway that is essential for cell-wall construction and bud emergence. However, little is known about its other functions. Now, Masaki Mizunuma and colleagues report that Pkc1p maintains polarized bud growth in an Mpk1p-independent manner (see p. 4219). The authors describe how yeast cells carrying pkc1-834, a novel mutant allele of PKC1, establish polarity normally but do not maintain polarized growth during cell budding. Maintenance of Ca²⁺-induced F-actin polarization is defective in these mutant yeast cells, and this phenotype is apparently caused by decreased expression of the G1 cyclin Cln2p. The authors propose that this novel Mpk1p-independent role for Pkc1p and its previously described Mpk1p-dependent role are important for the coordinated regulation of polar bud growth and the cell cycle.

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Related articles in JCS:

Implication of Pkc1p protein kinase C in sustaining Cln2p level and polarized bud growth in response to calcium signaling in Saccharomyces cerevisiae

Masaki Mizunuma, Dai Hirata, and Tokichi Miyakawa
JCS 2005 118: 4219-4229. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?