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Fig. 1. Comparison of C-terminal EHD protein architecture with other EHD proteins. Mammalian C-terminal EHD proteins comprise 534-541 amino acids and have three recognizable domains: an N-terminal nucleotide-binding region (light blue), a C-terminal EH domain (green), and a central coiled-coil region (gray). The motif homologous to the P-loop (or H-Ras G1 motif) is indicated, beginning with glycine at residue 65 (shown in red). Also denoted is the conserved tryptophan (W485) essential for EH-domain-mediated binding. For comparison, the EHD proteins Eps15 and intersectin1 are shown. These contain the following domains: DPW (orange); aspartate-proline-tryptophan; ubiquitin interacting motif, UIM (purple); src homology domain 3, SH3 (dark blue).





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