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Fig. 1. The salt bridge between Asp1 and Glu89. (a) Strand exchange in the C-cadherin structure 1L3W. The two domain 1 protomers are shown in blue and yellow respectively and Trp2 is coloured purple. Juxtaposition of the nitrogen of the N-terminal amino group of Asp1 (blue) and the oxygen atoms of the acidic side chain of Glu89 (red) are shown. (b) Cell surface staining of mutant and wild-type (Wt) N-cadherins expressed by K562 transfectants, matched for equal expression. The mutations Glu89Ala (E89A) and Gly-Gly (GG; in which the N-terminus was extended by two glycine residues) were present singly or together in the same molecule. The shaded profile is a negative control using FITC-labelled second antibody only.





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