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Fig. 1. Agonist-evoked shrinkage of submandibular acinar cells; effect of high extracellular K⁺. A control cluster of submandibular acinar cells (A; approx. eight cells), washed in Na⁺-rich extracellular medium containing the fluorescent dye, SRB and imaged with two-photon microscopy. (B) Fluorescent dye is excluded from the cell cytosol and dramatic decreases in cells volume in response to 10 µM ACh can readily be observed (B). (C) Superfusion with a K⁺-rich extracellular solution (trace i, black) prevented cell swelling but had no effect on the early intracellular Ca²⁺ response to ACh compared with control (trace ii, grey) as measured in Indo-1 loaded cells. Scale bar: 10 µm.

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