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Fig. 5. E4-ORF1 disrupts proper TJ localization of ZO-1 and ZO-2 in MDCK cells. (A) ZO-2 localization to TJs is impaired in MDCK-E4-ORF1 cells. Control MDCK-IIIA cells and MDCK-E4-ORF1 cells were immunostained with ZO-2 or SAP97 antibodies. Arrowheads indicate representative punctate bodies where ZO-2 becomes aberrantly sequestered in MDCK-E4-ORF1 cells. (B) Endogenous ZO-1 fails to associate with TJs in MDCK-E4-ORF1 cells. Control MDCK-IIIA cells and MDCK-E4-ORF1 cells were immunostained with ZO-1 (middle panels) and E4-ORF1 (left panels) antibodies. The combined images are shown in the right panels (merge). Scale bars: 20 µm (A); 40 µm (B).





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