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Fig. 1. Comparison of Dictyostelium PaxB with Human paxillin {alpha}. PaxB contains four conserved LD domain and four highly conserved Lim domains. PaxB does not contain any of the conserved tyrosine phosphorylation sites Y31 and Y118, which are part of SH2-binding domains in human paxillin, nor does it contain the proline-rich SH3-binding domain. A potential JNK phosphorylation site S178 (S192 in paxB) is conserved as are possible Erk phosphorylation sites S141 and S143.





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