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Fig. 2. MazF and RelE actions and structures. (A) E. coli MazF cleaves mRNAs in a sequence-dependent manner (see main text for details). (B) E. coli RelE affects mRNA cleavage, either directly or indirectly, in a ribosome- and codon-dependent manner (see main text for details). (C) The structure of the E. coli MazE-MazF complex: the two MazE molecules are shown in light and dark blue; the four MazF molecules are shown in yellow, green, pink and red. Reproduced with permission from Elsevier (Kamada et al., 2003). (D) The structure of the P. horikoshii RelB-RelE complex: RelE is shown in green and RelB is shown in red. Reproduced with permission from Nat. Struct. Mol. Biol. (Takagi et al., 2005).

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