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Fig. 3. Inhibition of PI3K attenuates the plasma membrane localization of PLD1 PX. NIH-3T3 cells transfected with pEGFP-PLD1 PX were serum starved for 24 hours. PDGF (25 ng/ml) was applied for 5 minutes, after the pre-incubation of cells with DMSO or 50 µM of the PI3K inhibitor LY 294002, for 20 minutes at 37°C. (A) Subcellular PLD1 PX localization was visualized by confocal microscopy. Bars, 10 µm. (B) Biochemical fractionation study showing localization of PLD1 PX in the cytosol (Cyt) or the plasme membrane (Mem), in the absence or presence of LY 294002.





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