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Fig. 6. Apoptin-induced cell death depends on Nur77, and involves its nucleo-cytoplasmic translocation. (A) Detection of Nur77 in MCF7 cells lipofected with scrambled or Nur77-targeting siRNA; protein was extracted at 0, 12, 24 and 30 hours post transfection. Tubulin was included as a loading control. (B) Cell viability of MCF7 cells treated with TAT-GFP (Control), transfected with Nur77 siRNA, or treated with TAT-apoptin (1 µM) either alone or in the presence of Nur77 siRNA, as determined by MTT assay at the indicated time points. (C) Confocal microscopy visualization of Nur77 (green) in MCF7 cells either left untreated or treated with TAT-apoptin for 30 hours. Mitochondria are stained by Mitotracker® (red), nuclei with DAPI (blue).





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