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Fig. 5. Endogenous SNX2 and SNX1 co-localise on tubular elements of the early endosome. Ultrathin cryosections of HepG2 cells showing the co-localization of SNX2 with SNX1 and CI-MPR on endosomal tubules. SNX2 (15 nm gold particles) and SNX1 (10 nm gold particles) co-localize on tubules emanating from endosomal (E) vacuoles (arrow in A) and on numerous vesicular-tubular profiles in close vicinity of endosomal vacuoles (arrows in B). SNX2 (15 nm gold particles) associates with CI-MPR (10 nm gold particles)-positive endosomal buds (arrows in C) and similar endosome-associated vesicular-tubular profiles, as shown in B (arrow in D). Bars, 200 nm





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