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First published online January 14, 2005

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Angiogenesis: the elastin connection

Angiogenesis - the formation of capillaries from pre-existing microvessels - is important in many normal and pathological processes, including embryogenesis and tumour development. On p. 343, Georges Bellon and colleagues report that elastin-derived peptides (EDPs) enhance angiogenesis through upregulation of membrane-type metalloproteinase 1 (MT1-MMP). EDPs are involved in many biological activities, their cellular effects being mediated through binding of a VGVAPG hexapeptide sequence to elastin-binding protein, a lectin-like receptor. The authors show that VGVAPG-motif-containing EDPs accelerate tubulogenesis in in vivo and in vitro models of angiogenesis and stimulate cell migration in a wound-healing assay. Furthermore, EDPs upregulate proMT1-MMP and proMMP-2 expression and activation, and EDP-mediated angiogenesis is triggered through elastin-binding protein. Then, by using small interfering RNAs specific for MT1-MMP, the authors reveal a crucial role for MT1-MMP in EDP-mediated angiogenesis. They conclude that EDPs, by upregulating MT1-MMP expression in endothelial cells, are important in processes in which matrix pericellular proteolysis, MT1-MMP endocytosis, MMP proteolytic activation cascades and/or cell surface receptor shedding are required for angiogenesis.

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Related articles in JCS:

Elastin-derived peptides enhance angiogenesis by promoting endothelial cell migration and tubulogenesis through upregulation of MT1-MMP

Arnaud Robinet, Abdel Fahem, Jean-Hubert Cauchard, Eric Huet, Loïc Vincent, Sandrine Lorimier, Franck Antonicelli, Claudine Soria, Michel Crepin, William Hornebeck, and Georges Bellon
JCS 2005 118: 343-356. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?